2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-13533
    DMPEN
    DMPEN (NSC 682691) (4-Demethylpenclomedine) is an alkylating metabolite of Penclomedine (HY-106401). DMPEN has an antitumor activity. DMPEN does not induce Purkinje cells loss with no significant neurocerebellar toxicity in rat cerebellum models. DMPEN can be used for cancers like breast and brain cancer research.
    DMPEN
  • HY-139199
    4-Hydroxyphenylbutazone
    4-Hydroxyphenylbutazone is a metabolite of Phenylbutazone. Phenylbutazone, a nonsteroidal anti-inflammatory agent (NSAID), is an efficient reducing cofactor for the peroxidase activity of prostaglandin H synthase (PHS).
    4-Hydroxyphenylbutazone
  • HY-W709612
    Regorafenib N-oxide and N-desmethyl (M5)-d3-1
    Regorafenib N-oxide and N-desmethyl (M5)-d3-1 (N-Desmethyl regorafenib N-oxide-d3-1) is the deuterium labeled Regorafenib N-oxide and N-desmethyl (M5) (HY-108226). Regorafenib N-oxide and N-desmethyl (M5) (N-Desmethyl regorafenib N-oxide) is an active metabolite of Sorafenib (HY-10201) and can be metabolized by CYP3A4.
    Regorafenib N-oxide and N-desmethyl (M5)-d<sub>3</sub>-1
  • HY-G0007R
    Omeprazole sulfone (Standard)
    Omeprazole sulfone (Standard) is the analytical standard of Omeprazole sulfone. This product is intended for research and analytical applications. Omeprazole sulfone (Omeprazole sulphone) is one of the major circulating metabolites of Omeprazole (HY-B0113) in vivo, and belongs to class 4 non-mutagenic impurities. Omeprazole sulfone does not bind to the aryl hydrocarbon receptor (AhR), nor does it induce the expression of CYP1A1 or CYP1A2. However, Omeprazole sulfone promotes the migration of gastric epithelial cells under basal conditions and reverses the inhibitory effect of Indomethacin (HY-14397) on cell migration. Omeprazole sulfone does not promote cell proliferation, nor does it upregulate COX-2 expression or activate signaling pathways such as ERK, P38 MAPK and PI3K. Omeprazole sulfone maintains basal ulcer healing under non-acid-dependent conditions and can be used in studies related to gastric ulcer repair.
    Omeprazole sulfone (Standard)
  • HY-100243A
    Norcisapride
    Norcisapride is a metabolite of cisapride (HY-14149). Norcisapride can be converted into UNK under CYP3A4.
    Norcisapride
  • HY-182475
    SQ 31906 free base
    SQ 31906 free base is the 3α-hydroxy isomer and metabolite of Pravastatin (HY-B0165). SQ 31906 free base forms via non-enzymatic reaction under acidic conditions. Pravastatin is used in hypercholesterolemia research.
    SQ 31906 free base
  • HY-N19800
    Anhydroicaritin-3,7-di-O-glucuronide
    Anhydroicaritin-3,7-di-O-glucuronide is a diglucuronide metabolite of icaritin. Anhydroicaritin-3,7-di-O-glucuronide is also a conjugated metabolite derived from prenylated flavonoids of the genus *Epimedium* in rats. In an in vitro microsomal system, Anhydroicaritin-3,7-di-O-glucuronide is mainly catalyzed by UGT1A1 and UGT1A8. Anhydroicaritin-3,7-di-O-glucuronide is generated via sequential glucuronidation at the 3-OH and 7-OH sites of icaritin, or via further conversion from monoglucuronides of icaritin.
    Anhydroicaritin-3,7-di-O-glucuronide
  • HY-135161
    EDDP perchlorate
    EDDP perchlorate is an N-desmethyl metabolite of Methadone by intestinal, hepatic, and cytochrome P450 (CYP) 3A4.
    EDDP perchlorate
  • HY-137324
    α-Apooxytetracycline
    α-Apooxytetracycline is a degradation product of Oxytetracycline (HY-B0275). Oxytetracycline is an antibiotic belonging to the tetracycline class.
    α-Apooxytetracycline
  • HY-100656R
    Desmethyl cariprazine (Standard)
    Desmethyl cariprazine (Standard) is the analytical standard of Desmethyl cariprazine (HY-100656). This product is intended for research and analytical applications. Desmethyl cariprazine is an active metabolite of Cariprazine. Cariprazine, an antipsychotic agent candidate, exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (2.6 nM).
    Desmethyl cariprazine (Standard)
  • HY-Z8143
    3-Keto fusidic acid
    3-Keto fusidic acid (3-keto FA) is a metabolite of Fusidic acid (HY-B1350) that is active when taken orally.
    3-Keto fusidic acid
  • HY-122489R
    DL-Laudanosine (Standard)
    DL-Laudanosine (Standard) is the analytical standard of DL-Laudanosine. This product is intended for research and analytical applications. DL-Laudanosine, an Atracurium and Cisatracurium metabolite, crosses the blood–brain barrier and may cause excitement and seizure activity.
    DL-Laudanosine (Standard)
  • HY-B1786R
    Sulindac sulfide (Standard)
    Sulindac sulfide (Standard) is the analytical standard of Sulindac sulfide. This product is intended for research and analytical applications. Sulindac sulfide is a noncompetitive γ-secretase inhibitor, with an IC50 of 20.2 μM for γ42-secretase activity.
    Sulindac sulfide (Standard)
  • HY-16445BR
    CNDAC hydrochloride (Standard)
    Dioscin (Standard) is the analytical standard of Dioscin. This product is intended for research and analytical applications. Dioscin (CCRIS 4123; Collettiside III) is a natural plant-derived steroidal saponin that has good anti-cancer activity against a variety of cancer cells. Dioscin causes DNA damage and induces apoptosis in HeLa and SiHa cells. Dioscin regulates ROS-mediated DNA damage and mitochondrial signaling pathways, exerting anticancer activity.
    CNDAC hydrochloride (Standard)
  • HY-185277
    6β-Hydroxy-7α-thiomethylspirolactone
    6β-Hydroxy-7α-thiomethylspirolactone is a metabolite of Spironolactone (HY-B0561). 6β-Hydroxy-7α-thiomethylspirolactone can be used in studies of cirrhotic ascites.
    6β-Hydroxy-7α-thiomethylspirolactone
  • HY-W704772
    S-Methyl-D-penicillamine
    		Control 99.57%
    S-Methyl-D-penicillamine is a metabolite of the chelating agent Penicillamine (HY-B0300).
    S-Methyl-D-penicillamine
  • HY-N4099R
    Luteolin-3-O-beta-D-glucuronide (Standard)
    Luteolin-3-O-beta-D-glucuronide (Standard) is the analytical standard of Luteolin-3-O-beta-D-glucuronide (HY-N4099). This product is intended for research and analytical applications. Luteolin-3-O-beta-D-glucuronide, a glucuronide derivative of Luteolin (HY-N0162), is found in the leaves of Rosmarinus officinalis L. Luteolin-3-O-beta-D-glucuronide inhibits nitrite production in macrophages and binds strongly to FYN kinase.
    Luteolin-3-O-beta-D-glucuronide (Standard)
  • HY-19197
    2-NAP
    2-NAP is a major metabolite of polycyclic aromatic hydrocarbons (PAHs). 2-NAP induces oxidative stress and inflammatory responses, impairs enamel formation, and disrupts oral microbiome balance, increasing the risk of early childhood caries (ECC). 2-NAP is promising for research of development-related diseases such as childhood caries.
    2-NAP
  • HY-133728
    Piribedil N-oxide
    Piribedil N-oxide is a metabolite of the dopamine receptor agonist Piribedil (HY-12707).
    Piribedil N-oxide
  • HY-W505108
    2,3-Dihydroxypropyl pentadecanoate
    		99.83%
    2,3-Dihydroxypropyl pentadecanoate is a monoacylglycerol that is found in wheat bran extracts. 2,3-Dihydroxypropyl pentadecanoate levels are increased in a HepaRG cell-based model of hepatic steatosis induced by BSA-conjugated palmitate.
    2,3-Dihydroxypropyl pentadecanoate
Cat. No. Product Name / Synonyms Application Reactivity